HCID 68579723, compound → HCID 68579806, compound

Participants

Reaction Steps

A mixture of tert-butyl 9-(1-hydroxycyclobutyl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (108 mg, 0.338 mmol) and 10% palladium on carbon (100 mg) in methanol (10 ml) was stirred at room temperature for 24 hr under a hydrogen atmosphere, and the insoluble material was filtered off. The filtrate was concentrated, and the residue was purified by silica gel column chromatography (hexane:ethyl acetate=1:1) to give the desired product (40.0 mg, 39.0%) as an oil.

Provenance & Evidence