Hydrogen chloride-ethyl acetate → 9-Cyclopropyl-2,3,4,5-tetrahydro-1,4-benzoxazepine hydrochloride

Participants

Reaction Steps

A mixture of tert-butyl 9-cyclopropyl-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (70.0 mg, 0.242 mmol), ethyl acetate (1 ml) and 4N hydrogen chloride-ethyl acetate solution (2 ml) was stirred at room temperature for 1 hr, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (29.5 mg, 54.0%) as a solid.

Provenance & Evidence