1-Chloroethyl chloroformate → HCID 68578547, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4-benzyl-9-cyclopropyl-8-fluoro-2,3,4,5-tetrahydro-1,4-benzoxazepine (408 mg, 1.37 mmol) and 1-chloroethyl chloroformate (0.178 ml, 1.65 mmol) in toluene (10 ml) was stirred at 90° C. for 2 hr, and the solvent was evaporated under reduced pressure. Methanol (10 ml) was added to the residue, the mixture was stirred at 80° C. for 1 hr, and diisopropyl ether (10 ml) was added. The precipitate was collected by filtration and recrystallized from a mixed solvent of ethanol and diisopropyl ether to give the desired product (295 mg, 88.5%) as a solid.

Provenance & Evidence