HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4,5-dichloro-2-methoxymethyl-2H-pyridazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4,5-Dichloro-3-hydroxypyridazine | HCID 73247 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Bromomethyl methyl ether | HCID 83093 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4,5-dichloro-2-methoxymethyl-2H-pyridazin-3-one | HCID 12351834 | 74.8% |
Reaction Steps
To a stirred solution of 4,5-dichloropyridazin-6-one (5.00 g, 30.3 mmol) and N,N-diisopropylethylamine (7.92 mL, 45.5 mmol) in methylenechloride (50 mL) was added slowly, bromomethyl methyl ether (4.79 mL, 60.6 mmol) at room temperature (water-bath). The reaction was stirred for 22 h and was then concentrated. Purification by column chromatography (1% MeOH in CH2Cl2) gave 4.74 g (74.8%) of 4,5-dichloro-2-methoxymethyl-2H-pyridazin-3-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247414B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-8587907189cd4873b7a565a27c252b45 |
| Source note | uspto-grants-2012_08 |