Ethyl 4-bromobutyrate → Ethyl 4-[4-(2-methoxyphenyl)piperazin-1-yl]butanoate

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Reaction Steps

Ethyl 4-(4-(2-methoxyphenyl)piperazin-1-yl)butanoate (17c) (Scheme 3) was synthesized from ethyl 4-bromobutanoate 16 and the piperazine 4 (R12═OMe, R13═H) according to protocol described for 17a (Example 19). Brown oil, 9.6 g (99%). 1H NMR (400 MHz, CDCl3): δ 1.23 (t, J=7.2 Hz, 3H), 1.82 (quintet, J=7.2 Hz, 2H); 2.35 (t, J=7.2 Hz, 2H); 2.43 (t, J=7.2 Hz, 2H); 2.63 (broad s, 4H); 3.07 (broad s, 4H); 3.84 (s, 3H); 4.13 (q, J=7.2 Hz, 2H); 6.83-6.99 (m, 4H). MS (ESI): m/z=307.50 (M+H+).

Provenance & Evidence