HCID 57420172, compound → HCID 57420174, compound

HRID 887063Notes

Reaction equation

HRID 887063 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][C:18]([O:20][C:21]2[CH:30]=[C:29]3[C:24]([CH2:25][CH2:26][C:27](=[O:31])[NH:28]3)=[CH:23][CH:22]=2)=[O:19])[CH2:11][CH2:10]1.Cl.COC1C=CC=CC=1N1CCN(CCCC(OC2C=C3C(CCC(=O)N3)=CC=2)=O)CC1>>[ClH:1].[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[N:9]1[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][CH2:17][C:18]([O:20][C:21]2[CH:30]=[C:29]3[C:24]([CH2:25][CH2:26][C:27](=[O:31])[NH:28]3)=[CH:23][CH:22]=2)=[O:19])[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 57420172HCID 57420172, compoundHCID 57420173HCID 57420173, compound

Product 1

HCID 57420174HCID 57420174, compound

Procedure

2-Oxo-1,2,3,4-tetrahydroquinolin-7-yl 4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butanoate hydrochloride (20b) (Scheme 3) was prepared from the compound 19b according to the protocol described for the compound 20a (Example 29). The hydrochloride salt 20b gave satisfactory 1H NMR spectral data. White solid, 0.11 g (98%). MS (ESI): m/z=462.1 (M+).

Sources & evidence

ORD record
ord-90ede9d1dad9465aac6f9404582fbb49
Source dataset
uspto-grants-2012_08
Patent number
US08247420B2

Reaction notes

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