2-Oxo-1,2,3,4-tetrahydroquinoline-7-carboxylic acid → 4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl 2-oxo-1,2,3,4-tetrahydroquinoline-7-carboxylate

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Reaction Steps

4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl 2-oxo-1,2,3,4-tetrahydroquinoline-7-carboxylate (23c) (Scheme 4) was synthesized from the compound 21c and the carboxylic acid 22 according to the protocol described for the compound 23a (Example 35). Off-white solid, 0.085 g (13%). 1H NMR (400 MHz, CDCl3): δ 1.66-1.72 (m, 2H); 1.78-1.84 (m, 2H); 2.47 (t, J=7.6 Hz, 2H); 2.63-2.67 (m, 6H); 3.01 (t, J=7.2 Hz, 2H); 3.09 (broad s, 4H); 3.84 (s, 3H); 4.34 (t, J=6.8 Hz, 2H); 6.83-7.00 (m, 4H); 7.21 (d, J=8.0 Hz, 1H); 7.47 (s, 1H); 7.66 (dd, J=1.6, 8.0 Hz, 1H); 8.61 (broad s, 1H). MS (ESI): m/z=438.20 (M+H+).

Provenance & Evidence