1-Piperazinebutanoic acid, 4-(2-methoxyphenyl)- → (2-Oxo-1,2,3,4-tetrahydroquinolin-7-yl)methyl 4-(4-(2-methoxyphenyl)piperazin-1-yl)butanoate

Participants

Role	Name	HCID	Charge
Reactant	1-Piperazinebutanoic acid, 4-(2-methoxyphenyl)-	HCID 11311981	—
Reactant	7-(Hydroxymethyl)-3,4-dihydroquinolin-2(1H)-one	HCID 53393348	—
Product	(2-Oxo-1,2,3,4-tetrahydroquinolin-7-yl)methyl 4-(4-(2-methoxyphenyl)piperazin-1-yl)butanoate	HCID 57420191	—

Reaction Steps

(2-Oxo-1,2,3,4-tetrahydroquinolin-7-yl)methyl 4-(4-(2-methoxyphenyl)piperazin-1-yl)butanoate (38c) (Scheme 7) was prepared from the carbinol 37 and the carboxylic acid 18c according to the protocol described for the compound 38a (Example 55). Colorless oil, 0.15 g (41%). 1H NMR (400 MHz, CDCl3): δ 1.84 (quintet, J=7.2 Hz, 2H); 2.38-2.54 (m, 4H); 2.58-2.60 (m, 6H); 2.95 (t, J=8.4 Hz, 2H); 3.03 (broad s, 4H); 3.80 (s, 3H); 5.02 (s, 2H); 6.80-6.94 (m, 4H); 7.09 (d, J=7.6 Hz, 1H); 9.30 (m, 1H). MS (ESI): m/z=438.20 (M+H+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08247420B2
Source dataset	uspto-grants-2012_08
ORD ID	ord-d70c4ef7430a42ad9495f2cc0ab63a89
Source note	uspto-grants-2012_08