1H-Indazol-4-amine, 1-methyl- → HCID 22337604, compound

HRID 887234Notes

Reaction equation

HRID 887234 reaction equation
[N:1]([CH2:4][C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:7][CH:6]=1)=[C:2]=[O:3].[CH3:16][N:17]1[C:25]2[CH:24]=[CH:23][CH:22]=[C:21]([NH2:26])[C:20]=2[CH:19]=[N:18]1.N1C2C=CC=C(N)C=2C=N1>>[CH3:16][N:17]1[C:25]2[C:20](=[C:21]([NH:26][C:2]([NH:1][CH2:4][C:5]3[CH:10]=[CH:9][C:8]([N:11]4[CH2:15][CH2:14][CH2:13][CH2:12]4)=[CH:7][CH:6]=3)=[O:3])[CH:22]=[CH:23][CH:24]=2)[CH:19]=[N:18]1

Participants

4

Reactant 3

HCID 1538381H-Indazol-4-amine, 1-methyl-HCID 413085NoName_3327HCID 22337618HCID 22337618, compound

Product 1

HCID 22337604HCID 22337604, compound

Procedure

The title compound was prepared using the procedure described in Example 89B using 1-[4-(isocyanatomethyl)phenyl]pyrrolidine and 1-methyl-1H-indazol-4-amine instead of 1-bromo-4-(isocyanatomethyl)benzene and the product from Example 89A. NMR (DMSO-d6) δ 8.98 (s, 1H), 8.16 (s, 1H), 7.63 (d, 1H), 7.13 (m, 3H), 7.12 (d, 1H), 6.94 (m, 1H), 6.73 (bs, 2H), 4.23 (s, 2H), 3.99 (s, 3H), 3.24 (m, 4H), 1.98 (m, 4H); MS (ESI) (M+H)+ 350.

Sources & evidence

ORD record
ord-11adc0c18f1342159b18c5ea49340ce8
Source dataset
uspto-grants-2012_08
Patent number
US08247413B2

Reaction notes

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