(alphaS)-4-Bromo-alpha-methylbenzenemethanamine → HCID 24992322, compound

HRID 887260Notes

Reaction equation

HRID 887260 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([NH2:10])[CH3:9])=[CH:4][CH:3]=1.[N:11]([C:14]1[CH:23]=[CH:22][CH:21]=[C:20]2[C:15]=1[CH:16]=[C:17]([CH3:24])[N:18]=[CH:19]2)=[C:12]=[O:13].N(C1C=CC=C2C=1C=CN=C2)=C=O>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([NH:10][C:12]([NH:11][C:14]2[CH:23]=[CH:22][CH:21]=[C:20]3[C:15]=2[CH:16]=[C:17]([CH3:24])[N:18]=[CH:19]3)=[O:13])[CH3:9])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 852999(alphaS)-4-Bromo-alpha-methylbenzenemethanamineHCID 115863575-IsocyanatoisoquinolineHCID 222283825-Isocyanato-3-methylisoquinoline

Product 1

HCID 24992322HCID 24992322, compound

Procedure

The title compound was prepared using the procedure described in Example 61B using (1S)-1-(4-bromophenyl)ethanamine and the product from Example 154A instead of 4-cyanobenzyl alcohol and the product from Example 61A.

Sources & evidence

ORD record
ord-dda468df7203459a893420d8ac9e9a4d
Source dataset
uspto-grants-2012_08
Patent number
US08247413B2

Reaction notes

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