HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-Morpholinobenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 4-Fluorobenzonitrile | HCID 14517 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 4-Morpholinobenzonitrile | HCID 394808 | — |
Reaction Steps
4-Fluorobenzonitrile (1 g, 8.26 mmol) and morpholine (2.2 mL, 25.2 mmol) were stirred in DMSO (25 mL) at 100° C. for 2.5 hours, cooled to room temperature, poured into H2O, and extracted with diethyl ether. The combined organic extracts were washed with H2O and brine, dried over Na2SO4, and evaporated in vacuo to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247413B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-61c041e4c2e848fa90fba53f18a10247 |
| Source note | uspto-grants-2012_08 |