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HRID 887300作成日：2026年10月25日

2,4-Dimethylbenzylamine → N-(2,4-dimethylbenzyl)-2-(5-isoquinolinyl)propanamide

https://huagongshe.com/reaction/887300

反応式

関与物質

役割名称HCID仕込み量
反応物2,4-DimethylbenzylamineHCID 66761—
反応物2-(Isoquinolin-5-YL)acetic acidHCID 12018708—
反応物2-(Isoquinolin-5-yl)propanoic acidHCID 22337638—
生成物N-(2,4-dimethylbenzyl)-2-(5-isoquinolinyl)propanamideHCID 10426039—

反応手順

The title compound was prepared using the procedure described in Example 222B using 2,4-dimethylbenzylamine and 2-(5-isoquinolinyl)propanoic acid instead of 4-(trifluoromethoxy)benzylamine and 5-isoquinolinylacetic acid. MS (ESI+) m/z 319 (M+H)+; MS (ESI−) m/z 317 (M−H)−; 1H NMR (DMSO, 300 MHz) δ 1.52 (d, J 7.1, 3H), 2.13 (s, 3H), 2.21 (s, 3H), 4.20 (m, 2H), 4.51 (q, J 7.1, 1H), 6.88 (d, J 7.5, 1H), 6.94 (s, 1H), 6.98 (d, J 7.5, 1H), 7.82 (t, J 7.8, 1H), 7.99 (d, J 6.5, 1H), 8.21 (d, J 8.1, 1H), 8.35 (d, J 6.4, 1H), 8.44 (t, J 5.8, 1H), 8.62 (d, J 6.2, 1H), 9.57 (s, 1H).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08247413B2
出典データセットuspto-grants-2012_08
ORD IDord-f624c8b060604160968a06fd040e9866
出典メモuspto-grants-2012_08