4-Bromobenzylamine → N-(4-bromobenzyl)-2-(5-isoquinolinyl)butanamide

참여 물질

역할	이름	HCID	투입량
반응물	4-Bromobenzylamine	HCID 77571	—
반응물	2-(Isoquinolin-5-YL)acetic acid	HCID 12018708	—
반응물	2-(Isoquinolin-5-yl)butanoic acid	HCID 22337682	—
생성물	N-(4-bromobenzyl)-2-(5-isoquinolinyl)butanamide	HCID 22032640	—

반응 단계

The title compound was prepared using the procedure described in Example 222B using 4-bromobenzylamine and 2-(5-isoquinolinyl)butanoic acid instead of 4-(trifluoromethoxy)benzylamine and 5-isoquinolinylacetic acid. MS (ESI+) m/z 385, 383 (M+H)+; MS (ESI−) m/z 383, 381 (M−H)−; 1H NMR (DMSO, 300 MHz) δ 0.91 (t, J 7.5, 3H), 1.81 (m, 1H), 2.19 (m, 1H), 3.39 (m, 1H), 4.22 (m, 2H), 7.13 (d, J 8.5, 2H), 7.44 (m, 3H), 7.57 (t, J 7.8, 1H), 8.00 (m, 1H), 8.21 (d, J 7.1, 1H), 8.41 (d, J 8.1, 1H), 8.72 (s, 1H), 8.93 (t, J 6.8, 1H), 9.81 (s, 1H), 10.16 (br s, 1H); Anal. Calcd for C20H19BrN2O: C, 62.67; H, 5.00. Found: C, 62.52; H, 4.95.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08247413B2
출처 데이터셋	uspto-grants-2012_08
ORD ID	ord-64e2aa31d1944316b6fea576bca26f02
출처 메모	uspto-grants-2012_08