HCID 59351436, compound → 1,1,1-trifluoro-2-(piperidin-4-yl)propan-2-ol

HRID 887380Notes

Reaction equation

HRID 887380 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([C:14]([OH:20])([CH3:19])[C:15]([F:18])([F:17])[F:16])[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[F:18][C:15]([F:16])([F:17])[C:14]([CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)([OH:20])[CH3:19]

Participants

4

Reactant 1

HCID 59351436HCID 59351436, compound

Product 1

HCID 509875341,1,1-trifluoro-2-(piperidin-4-yl)propan-2-ol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a stirred solution of 2-(1-benzylpiperidin-4-yl)-1,1,1-trifluoropropan-2-ol in methanol (25 mL), palladium on carbon (150 mg, 3.26 mmol) was added under hydrogen atmosphere. The resulting mixture was stirred under reflux for 6 h at 65 C. After completion of the reaction, the mixture was filtered and concentrated under vacuum to afford 1,1,1-trifluoro-2-(piperidin-4-yl)propan-2-ol. [M+H]=198.06

Workup

  1. temperatureunder reflux for 6 h at 65 C
  2. customAfter completion of the reaction
  3. filtrationthe mixture was filtered
  4. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-3b991f8d12524b1182927366fcfe5279
Source dataset
uspto-grants-2012_08
Patent number
US08247418B2

Reaction notes

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