Ethyl orthoformate → 5-Fluorobenzimidazole

Participants

Role	Name	HCID	Charge
Reactant	Ethyl orthoformate	HCID 31214	—
Reactant	4-Fluorobenzene-1,2-diamine	HCID 164584	—
Solvent	Ethanol	HCID 702	—
Product	5-Fluorobenzimidazole	HCID 235698	—

Reaction Conditions

Temperature	150 °C

Reaction Steps

To the solution of 4-fluoro-benzene-1,2-diamine (10 g, 79.4 mmol) and triethylorthoformate (117 mL, 793 mmol) was added few drop of ethanol and the reaction mixture was refluxed at 150° C. overnight. The reaction mixture was concentrated and the residue was directly taken to the next step. [M+H]=137.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08247418B2
Source dataset	uspto-grants-2012_08
ORD ID	ord-55385f5e23674ed5a2bf3443147fd061
Source note	uspto-grants-2012_08