HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Dichloropyrazine → HCID 59351251, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Dichloropyrazine | HCID 78575 | — |
| Reactant | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| Reactant | 2H-Pyran-4-carboxylic acid, tetrahydro-, methyl ester | HCID 2773520 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 59351251 | HCID 59351251 | — |
Reaction Steps
To a solution of 2,3-dichloropyrazine (1.45 g, 9.73 mmol) and methyl tetrahydro-2H-pyran-4-carboxylate (2.60 mL, 19.47 mmol) in Toluene (19.47 mL) at room temperature was added LiHMDS (19.47 mL, 19.47 mmol, 1M solution) dropwise. After overnight room temperature stirring, reaction was quenched with saturated NH4Cl solution and extracted with EtOAc. Purification by Biotage (0-10% MeOH/DCM) produced product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247418B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-8b31b83ffbac47e58bd39397f721d987 |
| Source note | uspto-grants-2012_08 |