HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloronicotinoyl chloride → 2-Chloro-N-[3-(2-pyrrolidin-1-yl-ethoxy)-4-trifluoromethyl-phenyl]-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloronicotinoyl chloride | HCID 2774541 | — |
| Reactant | 3-(2-Pyrrolidin-1-yl-ethoxy)-4-trifluoromethyl-phenylamine | HCID 21959457 | — |
| Reactant | 1-Boc-4-(3-[(2-chloro-pyridine-3-carbonyl)-amino]-5-trifluoromethyl-phenoxy}-piperidine | HCID 21959647 | — |
| Product | 2-Chloro-N-[3-(2-pyrrolidin-1-yl-ethoxy)-4-trifluoromethyl-phenyl]-nicotinamide | HCID 21959348 | — |
Reaction Steps
2-Chloro-N-[3-(2-pyrrolidin-1-yl-ethoxy)-4-trifluoromethyl-phenyl]-nicotinamide was prepared from 3-(2-pyrrolidin-1-yl-ethoxy)-4-trifluoromethyl-phenylamine and 2-chloropyridine-3-carbonyl chloride by a procedure similar to that described in the preparation of 1-Boc-4-{3-[(2-chloro-pyridine-3-carbonyl)-amino]-5-trifluoromethyl-phenoxy}-piperidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247430B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-e3a4922f67034fc8928d3285152c0898 |
| Source note | uspto-grants-2012_08 |