HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 887567Generated: October 30, 2026
1-Methylpiperazine → HCID 21959580, compound
https://huagongshe.com/reaction/887567
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 2-Bromo-1-tert-butyl-4-nitrobenzene | HCID 238587 | — |
| Product | HCID 21959580 | HCID 21959580 | — |
Reaction Steps
A mixture of 1-(tert-butyl)-2-bromo-4-nitrobenzene (3 g) and N-methylpiperazine (8 g) was heated neat at 130° C. for 4 h. The residue was purified by column chromatography to give 1-[4-bromo-5-(tert-butyl)-2-nitrophenyl]-4-methylpiperazine, which was hydrogenated to furnish 4-(tert-butyl)-2-(4-methylpiperazinyl)-phenylamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08247430B2 |
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| Source dataset | uspto-grants-2012_08 |
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| ORD ID | ord-c9dc60bf835a49b1b7a72af195e4b200 |
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| Source note | uspto-grants-2012_08 |
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