HCID 21961386, compound → 3-(3-Aminophenyl)-1-(4-methyl-1-piperazinyl)-1-propanone

HRID 887587Notes

Reaction equation

HRID 887587 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][C:12]([N:14]2[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]2)=[O:13])[CH:7]=[CH:8][CH:9]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][C:12]([N:14]2[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]2)=[O:13])[CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 1

HCID 21961386HCID 21961386, compound

Product 1

HCID 219595553-(3-Aminophenyl)-1-(4-methyl-1-piperazinyl)-1-propanone

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a nitrogen-degassed solution of 3-(3-nitrophenyl)-1-(4-methylpiperazinyl)propan-1-one (3.67 g, 13.330 mmol, Step A) in MeOH (50 ml) was added 10% by weight Pd/C (500 mg). The mix was stirred under H2 atmosphere for 18 h then filtered through Celite® and concentrated in vacuo, yielding a thick amber oil which eventually solidified into a dark pink solid.

Workup

  1. filtrationthen filtered through Celite®
  2. concentrationconcentrated in vacuo
  3. customyielding a thick amber oil which

Sources & evidence

ORD record
ord-65986c23ce5545a386fabfdbee960892
Source dataset
uspto-grants-2012_08
Patent number
US08247430B2

Reaction notes

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