Methanol → Methyl 2-(2,4-dinitrophenyl)acetate

HRID 887595노트

반응식

HRID 887595 반응식
[N+:1]([C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[CH:6][C:5]=1[CH2:13][C:14]([OH:16])=[O:15])([O-:3])=[O:2].OS(O)(=O)=O.[CH3:22]O>>[CH3:22][O:15][C:14](=[O:16])[CH2:13][C:5]1[CH:6]=[CH:7][C:8]([N+:10]([O-:12])=[O:11])=[CH:9][C:4]=1[N+:1]([O-:3])=[O:2]

참가 물질

4

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 2215132,4-Dinitrophenylacetic acid

생성물 1

HCID 286146Methyl 2-(2,4-dinitrophenyl)acetate

실험 절차

To a solution of (2,4-dinitro-phenyl)-acetic acid (5 g) in MeOH (100 mL) was added concentrated H2SO4 (1 mL) and the resulting solution was heated at reflux for overnight. After removing solvent in vacuum, the residue was partitioned between EtOAc and aqueous NaHCO3 (sat.). The organic solution was concentrated in vacuum to give the desired compound which was used without further purification.

후처리

  1. temperaturethe resulting solution was heated
  2. temperatureat reflux for overnight
  3. customAfter removing solvent in vacuum
  4. customthe residue was partitioned between EtOAc and aqueous NaHCO3 (sat.)
  5. concentrationThe organic solution was concentrated in vacuum

출처 및 근거

ORD 기록
ord-b3e380bb17184136974608d232eb1e40
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08247430B2

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