4-Nitro-2,3-dihydro-1H-isoindol-1-one → 4-amino-2,3-dihydro-1H-isoindol-1-one

Participants

Reaction Steps

To the suspension of 4-nitro-2,3-dihydro-isoindol-1-one (2.40 g, 13.5 mmol) in 100 ml of MeOH was added Pd/C (10 wt %, 0.36 g). The mixture was then placed under H2 from a balloon, stirred at RT for 24 h, filtered through Celite®, and condensed to give the titled compound as a light greenish solid. MS (ES+): 149.1 (M+H)+. Calc'd for C8H8N2O—148.16.

Provenance & Evidence