2-(Methylamino)pyridine-4-carbonitrile → (4-Aminomethyl-pyridin-2-yl)-methyl-amine

Participants

Reaction Steps

A suspension of 2-Methylamino-isonicotinonitrile (5.6 g) and Pd/C (10%, 4 g) in EtOH (150 mL) and TEA (40 mL) was placed in a 500 mL Parr Hydrogenation bottle and hydrogenated at or below 60 psi H2 pressure over night. After filtering through a pad of Celite®, the reaction mixture was concentrated in vacuo to give a yellow oil as the desired compound.

Provenance & Evidence