HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 887675Generated: October 30, 2026
Trifluoroacetic acid → 2-(Isoquinolin-7-ylamino)-N-(4-pentafluoroethyl-phenyl)-nicotinamide
https://huagongshe.com/reaction/887675
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Isoquinolin-7-amine | HCID 14660277 | — |
| Reactant | 2-fluoro-N-(4-pentafluoroethyl-phenyl)-nicotinamide | HCID 86093125 | — |
| Solvent | tert-Butanol | HCID 6386 | — |
| Product | 2-(Isoquinolin-7-ylamino)-N-(4-pentafluoroethyl-phenyl)-nicotinamide | HCID 11510869 | — |
Reaction Steps
To a mixture of 2-fluoro-N-(4-pentafluoroethyl-phenyl)-nicotinamide (112 mg) and 7-aminoisoquinoline (40 mg) in t-BuOH (0.5 mL) was added TFA (94 μL). The resulting mixture was stirred for 24 h at 90° C., cooled to RT and purified by flash chromatography (4:1:0.1; MeOH/CH2Cl2/MeOH) to give the title compound as a yellow solid. MS (ES+): 459 (M+H)+. Calc'd for C23H15F5N4O—458.12.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08247430B2 |
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| Source dataset | uspto-grants-2012_08 |
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| ORD ID | ord-c64a1a69a83e44b7a6154a887cce14fd |
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| Source note | uspto-grants-2012_08 |
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