HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 178493332, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Hydroxylamine HCl | HCID 21645 | — |
| Reactant | (8S)-4',9,9'-trihydroxy-6'-methoxy-1,1',3',5',8'-pentaoxospiro[6,7-dihydro-2H-cyclopenta[g]isoquinoline-8,2'-cyclopenta[b]naphthalene]-3-carbaldehyde | HCID 178493334 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178493332 | HCID 178493332 | — |
Reaction Steps
Ten (10) mg (19.4 μmol) fredericamycin aldehyde (4) are dissolved in 2 mL DMF. After addition of 3.1 mg (44.6 μmol) hydroxylammonium chloride, 3.2 μl pyridine are added. Stirring for 2 h at room temperature. The reaction mixture is added to 50 ml water and extracted 3 times with ethyl acetate. After drying and concentration, a deep red amorphous crystal powder was left (HPLC clean).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247424B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-93e3b1d57b9442bfa4db85bd7a5ab4d4 |
| Source note | uspto-grants-2012_08 |