HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 178493329, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | o-Benzylhydroxylammonium chloride | HCID 11094915 | — |
| Reactant | (8S)-4',9,9'-trihydroxy-6'-methoxy-1,1',3',5',8'-pentaoxospiro[6,7-dihydro-2H-cyclopenta[g]isoquinoline-8,2'-cyclopenta[b]naphthalene]-3-carbaldehyde | HCID 178493334 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178493329 | HCID 178493329 | — |
Reaction Steps
Ten (10) mg (19.4 μmol) fredericamycin aldehyde (4) are dissolved in 2 mL DMF. After addition of 6.4 mg (43.2 μmol) O-benzylhydroxylammonium chloride and 3.2 μl pyridine, the reaction mixture is stirred for 2 h at room temperature. Then, it is added to 50 ml water, and the supernatant is sucked off from the red precipitate (HPLC clean).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247424B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-4c53e1df81fa438792f13ecf6dcd3ac3 |
| Source note | uspto-grants-2012_08 |