Water → 2-(3-Bromo-1H-pyrazol-1-yl)-3-chloropyridine

Participants

Reaction Conditions

Reaction Steps

The crude product of 3-bromo-1H-pyrazole (10.7 g) was dissolved in DMF (80 mL), 2,3-dichloropyridine (11.8 g) and caesium carbonate (57.3 g) were added and the mixture was stirred for 8 h at 100° C. After addition of water, the mixture was extracted 2× with MTB-ether, the combined org. layers were washed 2× with water, brine, dried over MgSO4 and concentrated in vacuum. The residue was purified by column chromatography (silica gel 60, hexane/ethyl acetate=5:1, Rf=0.20) to afford 12.9 g of the title compound of the formula

Provenance & Evidence