2-Cyclopropyl-4-iodo-1-isopropyl-1H-imidazole → 4-(2-Cyclopropyl-1-isopropyl-1H-imidazol-4-ylethynyl)-2-methyl-pyridine

HRID 8877Notes

Reaction equation

HRID 8877 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][Si](C)(C)C)[CH:5]=[CH:4][N:3]=1.[CH:14]1([C:17]2[N:18]([CH:23]([CH3:25])[CH3:24])[CH:19]=[C:20](I)[N:21]=2)[CH2:16][CH2:15]1>>[CH:14]1([C:17]2[N:18]([CH:23]([CH3:25])[CH3:24])[CH:19]=[C:20]([C:9]#[C:8][C:6]3[CH:5]=[CH:4][N:3]=[C:2]([CH3:1])[CH:7]=3)[N:21]=2)[CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 219853902-Cyclopropyl-4-iodo-1-isopropyl-1H-imidazoleHCID 219853962-Methyl-4-((trimethylsilyl)ethynyl)pyridine

Product 1

HCID 692908434-(2-Cyclopropyl-1-isopropyl-1H-imidazol-4-ylethynyl)-2-methyl-pyridine

Procedure

The title compound, MS: m/e=266.3 (M+H+), was prepared in accordance with the general method of example A, step 2 from 2-methyl-4-trimethylsilanylethynyl-pyridine and 2-cyclopropyl-4-iodo-1-isopropyl-1H-imidazole.

Sources & evidence

ORD record
ord-cc6c42da646242948f4458d8f4479984
Source dataset
uspto-grants-2006_08
Patent number
US07091222B2

Reaction notes

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