Potassium Carbonate → 3-chloro-2-(3-(trifluoromethyl)-1H-pyrazol-1-yl)pyridine

Participants

Reaction Conditions

Reaction Steps

3-Trifluoromethyl-1H-pyrazole (15.30 g), 2,3-dichloro-pyridine (16.64 g) and potassium carbonate (26.42 g) were suspended in dry DMF (100 mL) and stirred for 3 h at 130° C., overnight at rt and again for 11 h at 130° C. After complete consumption of the starting material, the reaction was cooled to room temperature and quenched with water. The mixture was extracted 2× with ethyl acetate, the combined org. layers were washed 2× with water, brine, dried over MgSO4 and concentrated in vacuum. The residue was purified by column chromatography (silica gel 60, hexane/ethyl acetate=8:1, then 5:1, Rf=0.35 in hexane/ethyl acetate=3:1) to afford 22.88 g of the title compound of the formula

Provenance & Evidence