反应详情

To a solution of methyl 5-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]-2-methyl-2H-indazole-4-carboxylate (1.02 g, 3.72 mmol) in methanol (40 mL) was added palladium-carbon powder (100 mg), and the mixture was stirred under a hydrogen atmosphere at room temperature for 12 hr. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate) to give the title compound (813 mg, yield 79%).

1. filtrationThe catalyst was filtered off
2. concentrationthe filtrate was concentrated under reduced pressure
3. customThe residue was purified by silica gel column chromatography (ethyl acetate)