Methyl Acrylate → HCID 59145902, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of methyl 3-(acetylamino)-6-bromo-2-nitrobenzoate (500 mg, 1.58 mmol), palladium acetate (36.0 mg, 0.16 mmol), triphenylphosphine (84.0 mg, 0.32 mmol), potassium carbonate (328 mg, 2.37 mmol) and methyl acrylate (213 μL, 2.37 mmol) in N,N-dimethylformamide (15 mL) was stirred under a nitrogen atmosphere at 110° C. for 30 min with heating. The reaction solution was diluted with water, extracted with ethyl acetate, washed with water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane=25/75→55/45) to give the title compound (303 mg, yield 60%).

Provenance & Evidence