HCID 59145902, compound → HCID 59145879, compound

HRID 887749Notes

Reaction equation

HRID 887749 reaction equation
[C:1]([NH:4][C:5]1[C:6]([N+:21]([O-])=O)=[C:7]([C:12](/[CH:15]=[CH:16]/[C:17]([O:19][CH3:20])=[O:18])=[CH:13][CH:14]=1)[C:8]([O:10][CH3:11])=[O:9])(=[O:3])[CH3:2]>CO.[C].[Pd]>[C:1]([NH:4][C:5]1[C:6]([NH2:21])=[C:7]([C:12]([CH2:15][CH2:16][C:17]([O:19][CH3:20])=[O:18])=[CH:13][CH:14]=1)[C:8]([O:10][CH3:11])=[O:9])(=[O:3])[CH3:2]

Participants

4

Reactant 1

HCID 59145902HCID 59145902, compound

Product 1

HCID 59145879HCID 59145879, compoundYield 82.3%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

To a solution of methyl 3-(acetylamino)-6-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]-2-nitrobenzoate (686 mg, 2.13 mmol) in methanol (20 mL) was added palladium-carbon powder (20 mg), and the mixture was stirred under a hydrogen atmosphere at room temperature for 5 hr. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure to give the title compound (516 mg, yield 82%).

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-64ef0649051b44bab846f818e29002d6
Source dataset
uspto-grants-2012_08
Patent number
US08247429B2

Reaction notes

Loading…