反应详情

温度

80 °C

A solution of methyl 3-(acetylamino)-2-amino-6-(3-methoxy-3-oxopropyl)benzoate (490 mg, 1.66 mmol) in acetic acid (15 mL) was stirred with heating at 80° C. for 1 hr. The reaction solution was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (methanol/ethyl acetate=0/100→15/85) to give the title compound (434 mg, yield 95%).

1. concentrationThe reaction solution was concentrated under reduced pressure
2. customthe residue was purified by silica gel column chromatography (methanol/ethyl acetate=0/100→15/85)