Methyl 5-fluoro-2-methyl-3-nitrobenzoate → Methyl 3-amino-5-fluoro-2-methylbenzoate

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Reaction Steps

To a solution of methyl 5-fluoro-2-methyl-3-nitrobenzoate (3.20 g, 15.0 mmol) in methanol (150 mL) was added palladium-carbon powder (320 mg), and the mixture was stirred under a hydrogen atmosphere at room temperature for 4 hr. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure to give the title compound (1.47 g, yield 54%).

Provenance & Evidence