反应详情

To a solution of methyl 3-amino-5-fluoro-2-methylbenzoate (1.37 g, 7.48 mmol) in acetonitrile (57 mL) was added N-bromosuccinimide (1.01 g, 5.66 mmol) under ice-cooling, and the mixture was stirred for 2 hr. The reaction solution was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane=10/90→30/70) to give the title compound (1.33 g, yield 68%).

1. temperaturecooling
2. concentrationThe reaction solution was concentrated under reduced pressure
3. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane=10/90→30/70)