反应详情

To a solution of (5-fluoro-2-methyl-6,7-dihydrocyclopenta[e]indazol-8(2H)-ylidene)acetonitrile (156 mg, 0.686 mmol) in tetrahydrofuran/methanol (5 mL/5 mL) were added Raney cobalt (1.5 g) and 2M ammonia/methanol solution (2 mL), and the mixture was stirred under a hydrogen atmosphere at room temperature for 4 hr. The catalyst was filtered off through celite, and the filtrate was concentrated under reduced pressure to give the title compound (157 mg, yield 99%).

1. filtrationThe catalyst was filtered off through celite
2. concentrationthe filtrate was concentrated under reduced pressure