反应详情

To a solution of N-[2-(2-methyl-6,7-dihydrocyclopenta[e]indazol-8(2H)-ylidene)ethyl]acetamide (311 mg, 1.22 mmol) in methanol (12 mL) was added palladium-carbon powder (31 mg), and the mixture was stirred under a hydrogen atmosphere at room temperature for 3 hr. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure and purified by silica gel column chromatography (methanol/ethyl acetate=0/100→25/75) to give the title compound (229 mg, yield 73%).

1. filtrationThe catalyst was filtered off
2. concentrationthe filtrate was concentrated under reduced pressure
3. custompurified by silica gel column chromatography (methanol/ethyl acetate=0/100→25/75)