HCID 68697791, compound → HCID 59145935, compound

HRID 887804Notes

Reaction equation

HRID 887804 reaction equation
[CH3:1][C:2]1[N:3]([CH3:20])[N:4]=[C:5]2[C:10]=1[C:9]1[C:11](=[CH:14][CH2:15][NH:16][C:17](=[O:19])[CH3:18])[CH2:12][CH2:13][C:8]=1[CH:7]=[CH:6]2>CO.[C].[Pd]>[CH3:1][C:2]1[N:3]([CH3:20])[N:4]=[C:5]2[C:10]=1[C:9]1[CH:11]([CH2:14][CH2:15][NH:16][C:17](=[O:19])[CH3:18])[CH2:12][CH2:13][C:8]=1[CH:7]=[CH:6]2

Participants

4

Reactant 1

HCID 68697791HCID 68697791, compound

Product 1

HCID 59145935HCID 59145935, compoundYield 68%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

To a solution of N-[2-(1,2-dimethyl-6,7-dihydrocyclopenta[e]indazol-8(2H)-ylidene)ethyl]acetamide (55.7 mg, 0.207 mmol) in methanol (2 mL) was added palladium-carbon powder (10 mg), and the mixture was stirred under a hydrogen atmosphere at room temperature for 7 hr. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure and purified by thin layer chromatography (methanol/ethyl acetate=13/87) to give the title compound (38.2 mg, yield 68%).

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. custompurified by thin layer chromatography (methanol/ethyl acetate=13/87)

Sources & evidence

ORD record
ord-8a7e399952044cc69158a58681c35113
Source dataset
uspto-grants-2012_08
Patent number
US08247429B2

Reaction notes

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