Bromoacetone → HCID 59145920, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of N-[2-(2-amino-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl)ethyl]acetamide (17.6 mg, 0.0803 mmol), bromoacetone (16.5 mg, 0.120 mmol) and sodium hydrogen carbonate (10.1 mg, 0.12 mmol) in ethanol (1 mL) was heated under reflux for 4 hr. The solvent was evaporated under reduced pressure, and N,N-dimethylformamide (1 mL) was added. The mixture was irradiated with 150 W microwave and stirred at 160° C. for 30 min. The solvent was evaporated under reduced pressure, and the residue was purified by thin layer chromatography (methanol/ethyl acetate=17/83 and NH; methanol/ethyl acetate=5/95) to give the title compound (2.0 mg, yield 10%).

Provenance & Evidence