N-bromobutanimide → N-{2-[(8S)-1-bromo-2-methyl-2,6,7,8-tetrahydrocyclopenta[e]indazol-8-yl]ethyl}acetamide

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Reaction Steps

To a solution of N-{2-[(8S)-2-methyl-2,6,7,8-tetrahydrocyclopenta[e]indazol-8-yl]ethyl}acetamide (50 mg, 0.194 mmol) in acetonitrile (2.0 mL) was added N-bromosuccinimide (34.6 mg, 0.194 mmol), and the mixture was stirred at room temperature for 15 min. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (methanol/ethyl acetate=0/100→5/95) to give the title compound (60.3 mg, yield 92%).

Provenance & Evidence