Hydrochloric Acid → HCID 178478679, compound

Participants

Reaction Steps

A suspension of 0.715 g of the compound of Example 1 (2.2 mmol), 0.303 mg of 2-chloropyrimidine and 0.47 g of sodium carbonate in 45 ml of ethanol is heated at reflux for 72 hours. After filtering, the solvents are then evaporated off After extraction with ethyl acetate and drying (MgSO4), evaporation yields an oil which is purified by chromatography on a silica column using a mixture of dichloromethane/methanol/ammonium hydroxide (98/2/0.2) as eluant to yield, after converting to a salt in ethanol in the warm state using 1N ethereal HCl, the title product.

Provenance & Evidence