HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-6-(2,4-dichloro-phenyl)-5-trifluoromethyl-pyridine-2-carboxylic acid → US10117858, Example 9
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-6-(2,4-dichloro-phenyl)-5-trifluoromethyl-pyridine-2-carboxylic acid | HCID 58442340 | — |
| Reactant | 3-Amino-1,1,1-trifluoro-2-methylpropan-2-ol hydrochloride | HCID 71757351 | — |
| Product | US10117858, Example 9 | HCID 58442319 | — |
Reaction Steps
The enantiomers of 3-amino-6-(2,4-dichloro-phenyl)-5-trifluoromethyl-pyridine-2-carboxylic acid (3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-amide were prepared from 3-Amino-6-(2,4-dichloro-phenyl)-5-trifluoromethyl-pyridine-2-carboxylic acid (Intermediate H) and 3-amino-1,1,1-trifluoro-2-methylpropan-2-ol hydrochloride analogously to Example 1 and separated by chiral separation using Supercritical Fluid Chromatography:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247436B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-f52590ee43b44084b00674ff89501a09 |
| Source note | uspto-grants-2012_08 |