Hydrazine → 3,3,3-Trifluoro-2-methoxy-2-methylpropan-1-amine

HRID 887889Notes

Reaction equation

HRID 887889 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]([O:17][CH3:18])([CH3:16])[CH2:4][N:5]1C(=O)C2C(=CC=CC=2)C1=O.NN>>[F:1][C:2]([F:20])([F:19])[C:3]([O:17][CH3:18])([CH3:16])[CH2:4][NH2:5]

Participants

3

Reactant 2

HCID 9321HydrazineHCID 67383555HCID 67383555, compound

Product 1

HCID 584423513,3,3-Trifluoro-2-methoxy-2-methylpropan-1-amine

Procedure

A mixture comprising 2-(3,3,3-trifluoro-2-methoxy-2-methylpropyl)isoindoline-1,3-dione (272 mg, 0.95 mmol) and hydrazine (0.033 ml, 1.045 mmol) was stirred at 75° C. for 4 hours. After cooling to RT, the mixture was filtered and the filtrate was concentrated in vacuo to afford the title product which was used without further purification (no characterisation data available).

Workup

  1. filtrationthe mixture was filtered
  2. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-8b07b57a3cde4f8d920182349f32dbd0
Source dataset
uspto-grants-2012_08
Patent number
US08247436B2

Reaction notes

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