HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 1-(2-Chloro4,5-difluorobenzoyl)-3-(2-methoxy-5-nitrophenyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 2-Methoxy-5-nitroaniline | HCID 7447 | — |
| Reactant | 2-Chloro-4,5-difluorobenzoyl Isocyanate | HCID 11557583 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 1-(2-Chloro4,5-difluorobenzoyl)-3-(2-methoxy-5-nitrophenyl)urea | HCID 11668152 | 79% |
Reaction Steps
4.0 g (23.8 mmol) of 2-methoxy-5-nitroaniline were dissolved in 10 ml of N-methyl-2-pyrrolidinone, and 5.2 g (23.8 mmol) of 2-chloro-4,5-difluorobenzoyl isocyanate were added. Slight warming occurred. After 15 minutes at room temperature, diethyl ether was added, and the resulting precipitate was filtered off with suction. 6.6 g (79%) of the desired product were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247452B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-e72eac6b62c34bb68ed3ed23452198ea |
| Source note | uspto-grants-2012_08 |