HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Isocyanate → Glycogen Phosphorylase Inhibitor
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Isocyanate | HCID 12228 | — |
| Reactant | 1-(2-Chloro-4,5-difluorobenzoyl)-3-(5-amino-2-methoxyphenyl)urea | HCID 11566579 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Glycogen Phosphorylase Inhibitor | HCID 10070301 | 91% |
Reaction Steps
600 mg (1.7 mmol) of 1-(5-amino-2-methoxyphenyl)-3-(2-chloro-4,5-difluoro-benzoyl)urea were dissolved in 5 ml of acetonitrile, and 69 mg (1.7 mmol) of methyl isocyanate were added. After stirring at room temperature for one hour, the resulting precipitate was filtered off with suction. 638 mg (91%) of the desired product were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247452B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-f817b42c8b09429f9edb9a88ec90dfc4 |
| Source note | uspto-grants-2012_08 |