2-(Trifluoromethyl)phenyl isocyanate → HCID 86592175, compound

HRID 887899Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][C:10]([O:12][CH3:13])=[O:11])=[C:4]([NH:14][C:15]([NH:17][C:18](=[O:28])[C:19]2[CH:24]=[C:23]([F:25])[C:22]([F:26])=[CH:21][C:20]=2[Cl:27])=[O:16])[CH:3]=1.[F:29][C:30]([F:41])([F:40])[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[N:37]=[C:38]=[O:39]>C(#N)C>[Cl:27][C:20]1[CH:21]=[C:22]([F:26])[C:23]([F:25])=[CH:24][C:19]=1[C:18]([NH:17][C:15](=[O:16])[NH:14][C:4]1[CH:3]=[C:2]([NH:1][C:38]([NH:37][C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=2[C:30]([F:29])([F:40])[F:41])=[O:39])[CH:7]=[CH:6][C:5]=1[CH:8]=[CH:9][C:10]([O:12][CH3:13])=[O:11])=[O:28]

Participants

Conditions

Temperature: 60 °C

Procedure

100 mg (0.24 mmol) of methyl 3-{4-amino-2-[3-(2-chloro-4,5-difluorobenzoyl)-ureido]phenyl}acrylate were dissolved in 1 ml of acetonitrile and mixed with 2-trifluoromethylphenyl isocyanate and shaken at 60° C. for 14 hours. The resulting precipitate was filtered off with suction, and 16 mg (11%) of the desired product were obtained.

Workup

filtrationThe resulting precipitate was filtered off with suction

Sources & evidence

ORD record: ord-a7de984cbd734850a545dc17cfd312ca
Source dataset: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08247452B2

Reaction notes

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