反应详情

34 g (0.19 mol) of N-(4-methoxy-2-methylphenyl)acetamide were added in small portions to a mixture of 40 ml of glacial acetic acid and 70 ml of fuming nitric acid at −10 to −15° C. These portions were such that the temperature did not rise above −10° C. The reaction mixture was then poured onto ice. The resulting precipitate was filtered off with suction and washed with water, ethanol and diethyl ether. 22.5 g (53%) of the desired product were obtained.

1. customdid not rise above −10° C
2. additionThe reaction mixture was then poured onto ice
3. filtrationThe resulting precipitate was filtered off with suction
4. washwashed with water, ethanol and diethyl ether