HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 887906Generated: October 29, 2026
Oxalyl chloride → 6-Methoxy-7-nitroquinazoline-2,4(1H,3H)-dione
https://huagongshe.com/reaction/887906
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-Amino-5-methoxy-4-nitrobenzamide | HCID 68806743 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-Methoxy-7-nitroquinazoline-2,4(1H,3H)-dione | HCID 68804811 | 100% |
Reaction Steps
108 mg (0.5 mmol) of 2-amino-5-methoxy-4-nitrobenzamide were dissolved in 5 ml of tetrahydrofuran and 5 ml of chloroform, and oxalyl chloride (solution in toluene) was added. The mixture was stirred at 60° C. for 5 hours and then concentrated in vacuo. Addition of toluene was followed by renewed concentration. 120 mg (100%) of the desired product were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08247452B2 |
|---|
| Source dataset | uspto-grants-2012_08 |
|---|
| ORD ID | ord-013b2269be7a45b5ae5308ee0da1ac3e |
|---|
| Source note | uspto-grants-2012_08 |
|---|
