反应详情

1-Hydroxybenzotriazole hydrate (0.00318 mole) was added to a solution of compound 105 (0.00159 mole) in DCM (160 mL) at room temperature. N,N′-methane-tetrayl-biscyclohexanamine (0.00206 mole) was added neat at room temperature. After 60 minutes, NH3 gas was bubbled in for 5 minutes, and a solid precipitated out. The mixture was allowed to sit over the weekend. The mixture was filtered, and the filtrate was extracted with saturated NaHCO3. The organic phases were dried over MgSO4, filtered, and concentrated. The residue was purified by liquid chromatography, yielding 0.21 g of 1,1-dimethylethyl 2-[4-(aminocarbonyl)-5-propyl-1H-imidazol-2-yl]-2,3-dihydro-1H-indole-1-carboxylate (compound 106).

1. customNH3 gas was bubbled in for 5 minutes
2. customa solid precipitated out
3. filtrationThe mixture was filtered
4. extractionthe filtrate was extracted with saturated NaHCO3
5. dry with materialThe organic phases were dried over MgSO4
6. filtrationfiltered
7. concentrationconcentrated
8. customThe residue was purified by liquid chromatography