Hydrogen Bromide → Clopidogrel hydrobromide

Participants

Reaction Conditions

Reaction Steps

Clopidogrel (10 g) obtained from example 3 was dissolved in diisopropyl ether (129.3 ml) at 25-30° C. and 47% aqueous hydrobromic acid solution (3.79 ml) was added dropwise in 30 minutes at 25-30° C. The resulting suspension was stirred for 3 hours at 25-30° C. The resulting crude solid was filtered, washed with diisopropyl ether (10 ml) at 25-30° C. and dried under reduced pressure at 30-35° C. for 15 hours.

Provenance & Evidence