Sulfuric Acid → Clopidogrel Bisulfate

Participants

Reaction Conditions

Reaction Steps

Clopidogrel (10 g) obtained from example 3 was dissolved in acetone (43 ml) at 5-10° C. and concentrated sulfuric acid (1.78 ml) was added dropwise in 10 minutes at 5-10° C. The resulting solution was stirred for 1 hour at 5-10° C. The resulting solid was filtered and dried under reduced pressure at 50° C. for 5 hours.

Provenance & Evidence